Correction to An Azobenzene Photoswitch Sheds Light on Turn Nucleation in Amyloid-β Self-Assembly
نویسندگان
چکیده
منابع مشابه
Study of Cis–trans Isomerization Mechanism of [3-(3-Aminomethyl) Phenylazo] Phenyl Acetic Acid as a Causative Role in Alzheimer Using Density Functional Theory
Amyloid-β (Aβ) self-assembly into cross-β amyloidfibrils is implicated in a causative role in Alzheimer’s disease pathology.Uncertainties persist regarding the mechanisms of amyloid self assembly and the role of metastable prefibrillar aggregates. Aβ fibrilsfeature a sheet-turn-sheet motif in the constituent β-strands; as such, turn nucleation has been proposed as a rate-limiting step in the se...
متن کاملStudy of Cis–trans Isomerization Mechanism of [3-(3-Aminomethyl) Phenylazo] Phenyl Acetic Acid as a Causative Role in Alzheimer Using Density Functional Theory
Amyloid-β (Aβ) self-assembly into cross-β amyloidfibrils is implicated in a causative role in Alzheimer’s disease pathology.Uncertainties persist regarding the mechanisms of amyloid self assembly and the role of metastable prefibrillar aggregates. Aβ fibrilsfeature a sheet-turn-sheet motif in the constituent β-strands; as such, turn nucleation has been proposed as a rate-limiting step in the se...
متن کاملstudy of cis–trans isomerization mechanism of [3-(3-aminomethyl) phenylazo] phenyl acetic acid as a causative role in alzheimer using density functional theory
amyloid-β (aβ) self-assembly into cross-β amyloidfibrils is implicated in a causative role in alzheimer’s disease pathology.uncertainties persist regarding the mechanisms of amyloid self assembly and the role of metastable prefibrillar aggregates. aβ fibrilsfeature a sheet-turn-sheet motif in the constituent β-strands; as such, turn nucleation has been proposed as a rate-limiting step in the se...
متن کاملError Correction for DNA Self-Assembly: Preventing Facet Nucleation
Abstract. Algorithmic self-assembly has been proposed as a mechanism for bottom-up construction of nanostructures and autonomous DNA computation. For these applications, we are often interested in assembling large systems with great precision. However, several effects present in real systems result in errors with respect the the abstract Tile Assembly Model used for most theoretical studies. He...
متن کاملProbing aromatic, hydrophobic, and steric effects on the self-assembly of an amyloid-β fragment peptide.
Aromatic amino acids have been shown to promote self-assembly of amyloid peptides, although the basis for this amyloid-inducing behavior is not understood. We adopted the amyloid-β 16-22 peptide (Aβ(16-22), Ac-KLVFFAE-NH(2)) as a model to study the role of aromatic amino acids in peptide self-assembly. Aβ(16-22) contains two consecutive Phe residues (19 and 20) in which Phe 19 side chains form ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: ACS Chemical Neuroscience
سال: 2012
ISSN: 1948-7193,1948-7193
DOI: 10.1021/cn300032g